Rat Plasma With EDTA is a Rat Plasma with EDTA This product has been used as molecular tool for various biochemical applications It has also been used in a wide array of other chemical and immunological applications For in vitro research use only
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A dual peptide GCGR and GLP-1R agonist induces cAMP production in BHK-21 cells expressing human GCGR or GLP-1R (EC50s 1.83 and 0.92 pM respectively) reduces body weight and cumulative food intake in a mouse model of diet-induced obesity from 3-5 nmol/kg reduces body weight hepatic fat accumulation and fibrosis and plasma ALT levels in a mouse model of NASH induced by a high-fat high-fructose and high-cholesterol diet
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An inhibitor of Factor XIa (IC50 0.92 nM) greater than 1000-fold selective for Factor Xa over FVIIa FIXa FXa thrombin urokinase tissue plasminogen activator and plasmin increases clotting time in isolated human plasma (EC150 0.2 UM) reduces thrombus weight in a rabbit model of thrombosis induced by ferric chloride injury of the carotid artery
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A P2X7 receptor antagonist inhibits ATP-induced dye uptake in HEK293 cells expressing human purinergic P2X7 receptors (IC50 22.4 nM) inhibits common lancehead (B. atrox) venom proteolysis in a concentration-dependent manner inhibits ATP-induced IL-1B secretion in human THP-1 monocytes and primary mouse peritoneal macrophages (IC50s 9.8 and 11.2 nM respectively) inhibits common lancehead (B. atrox) and jararaca (B. jararaca) venom-induced skin hemorrhage in mice when intradermally administered at 3 mg/kg inhibits carrageenan-induced paw edema in mice at 0.01 to 1 mg/kg
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A PAK1 inhibitor (IC50 0.33 nM) selective for PAK1 over a panel of 117 kinases at 100 nM binds to PAK1 and PAK2 (Kd 0.28 and 0.32 nM respectively) inhibits S. enterica infection in HAP1 cells at 10 UM inhibits cell death induced by an antibody targeting Siglec-8 in IL-5-stimulated primary human eosinophils (IC50 59 nM)
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An inhibitor of ATM kinase (IC50 0.78 nM) selective for ATM over ATR PI3K mTOR and DNA-PK (IC50s 30 12 16 and 29.9 UM respectively) sensitizes glioma cells expressing mutant but not wild-type p53 to ionizing radiation reduces the growth of brain metastases and increases survival in an NCI H2228 mouse xenograft model at 20 mg/kg twice daily p.o. in combination with radiation
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EDTA (Ethylenediaminetetraacetic acid) is a chelating agent, a general chemical and a sequestrant. In molecular biology applications, it is used to minimize metal ion contamination and prevent enzymatic activity.
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